Hydroxy-PEG3-t-butyl acetate Chemical Properties

Boiling point:

351.2±27.0 °C(Predicted)

Density 

1.071±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

14.36±0.10(Predicted)

form 

viscous liquid

color 

Colourless

InChI

InChI=1S/C12H24O6/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h13H,4-10H2,1-3H3

InChIKey

YZXRUQCLSBHYHG-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)COCCOCCOCCO

Safety Information

HS Code 

2942000090

Hydroxy-PEG3-t-butyl acetate Usage And Synthesis

Description

Hydroxy-PEG3-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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