Hydroxy-PEG6-CH2CO2tBu Chemical Properties

Boiling point:

469.5±40.0 °C(Predicted)

Density 

1.086±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

Hydroxy-PEG6-CH2CO2tBu Usage And Synthesis

Description

Hydroxy-PEG6-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Hydroxy-PEG6-CH2CO2tBu(297162-47-1)Related Product Information

• Hydroxy-PEG2-CH2CO2H
• Hydroxy-PEG5-t-butyl acetate
• tert-butyl 29-hydroxy-3,9,14,19,24-pentaoxanonacosanoate
• tert-butyl 21-hydroxy-3,6,11,16,19-pentaoxahenicosanoate
• Hydroxy-PEG1-CH2CO2tBu
• Hydroxy-PEG2-CH2CO2t-Bu
• Azido-PEG1-CH2CO2tBu
• Azido-PEG4-t-butyl acetate
• Bromo-PEG2-CH2CO2tBu
• PEG6-(CH2CO2H)2
• 2-(4-OCTYLPHENYL)ETHANOL
• PEG4-tert-butyl acetate
• Hydroxy-PEG3-t-butyl acetate
• Bromo-PEG1-CH2CO2tBu