Bromo-PEG5-phosphonic acid ethyl ester Usage And Synthesis

Description

Bromo-PEG5-phosphonic acid diethyl ester is a PEG linker containing a bromine and a hydrophilic PEG chain. The size and electronegative properties of bromine make it a good leaving group and able to participate in substitution reactions. The hydrophilic PEG linker increases the compound's solubility in aqueous media.

Uses

Bromo-PEG5-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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