Bromo-PEG3-phosphonic acid Chemical Properties

Boiling point:

458.1±55.0 °C(Predicted)

Density 

1.514±0.06 g/cm3(Predicted)

pka

2.14±0.10(Predicted)

Bromo-PEG3-phosphonic acid Usage And Synthesis

Description

Bromo-PEG3-phosphonic acid is a PEG linker with bromine and phosphonic acid moieties. The bromine is a good leaving group. The hydrophilic PEG chain increases compound solubility in aqueous media.

Uses

Bromo-PEG3-C2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromo-PEG3-phosphonic acid(1148026-99-6)Related Product Information

• Bromo-PEG4-t-butyl ester
• Bromo-PEG2-acid
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• Bromo-PEG4-acid
• Bromo-PEG5-phosphonic acid ethyl ester
• Broxuridine
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• 2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro-
• Bromo-PEG5-phosphonic acid
• Br-PEG6-acid
• 2H-Pyran, 2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]tetrahydro-
• Bromo-PEG3-phosphonic acid ethyl ester
• Br-PEG5-NHBoc
• Br-PEG1-COOtBu
• Br-PEG6-THP
• Methanesulfonic acid 2-bromoethyl ester