Bromo-PEG5-phosphonic acid Usage And Synthesis

Description

Bromo-PEG5-phosphonic acid is a hydrophilic PEG linker containing a bromine group and a phosphonic acid group. The bromine is a good leaving group. The hydrophilic PEG chain increases the water solubility of compounds in aqueous media.

Uses

Bromo-PEG5-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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