Basic information Safety Supplier Related

4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE

Basic information Safety Supplier Related

4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE Basic information

Product Name:
4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE
Synonyms:
  • 4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE
  • Immepip
  • 4-(1H-imidazol-5-ylmethyl)piperidine
  • Piperidine, 4-(1H-imidazol-5-ylmethyl)-
CAS:
151070-83-6
MF:
C9H15N3
MW:
165.2355
Mol File:
151070-83-6.mol
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4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE Chemical Properties

Boiling point:
377.4±22.0 °C(Predicted)
Density 
1.084±0.06 g/cm3(Predicted)
pka
14?+-.0.10(Predicted)
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4-(1H-IMIDAZOL-4-YLMETHYL)-PIPERIDINE Usage And Synthesis

Uses

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases[1].

Definition

ChEBI: Immepip is a member of piperidines.

in vivo

Immepip (i.p.; 5, 10 mg/kg) markedly reduces cortical histamine release, but only weakly promotes sleep in the rat[1].

Animal Model:Sprague-Dawley rats[1]
Dosage:5, 10 mg/kg
Administration:Intraperitoneally
Result:Significantly modulated brain histamine release and slight, albeit significant, decreased in sleep onset latency.

References

[1] Yves Lamberty, et al. H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat. Pharmacol Res. 2003 Aug;48(2):193-8. DOI:10.1016/s1043-6618(03)00094-x

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