Ulocuplumab
Ulocuplumab Basic information
- Product Name:
- Ulocuplumab
- Synonyms:
-
- Ulocuplumab
- Research Grade Ulocuplumab(DHF39901)
- Ulocuplumab (anti-CXCR4)
- BMS 936564|||MDX 1338
- Research Grade Ulocuplumab
- CAS:
- 1375830-34-4
- MW:
- 0
- Mol File:
- Mol File
Ulocuplumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Ulocuplumab Usage And Synthesis
Uses
Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models[1][2].
in vivo
Ulocuplumab (3-30 mg/kg; i.p.; every 3-4 days for 5 doses; 65 days in total) inhibits tumor growth of multiple myeloma xenograft models in mice, including Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells models[1].
| Animal Model: | Severe combined immunodeficient (SCID) mice of AML model (MOLP-8 cells)[1] |
| Dosage: | 3-30 mg/kg |
| Administration: | Intraperitoneal injection; every 3-4 days for 5 doses; last for 65 days |
| Result: | Significantly delayed mean tumor growth by 66% and 56% when compared with isotype control on day 25. |
IC 50
CXCR4
References
[1] Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7(3):2809-22. DOI:10.18632/oncotarget.6465
[2] Kuhne MR, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. DOI:10.1158/1078-0432.CCR-12-2333
UlocuplumabSupplier
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- 15817493340
- 981810490@qq.com
- Tel
- 027-65317797 15926423062
- 422450190@qq.com