WM-3835 Chemical Properties

Density 

1.369±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 250 mg/mL (624.34 mM; Need ultrasonic)

pka

7.26±0.25(Predicted)

form 

Solid

color 

White to off-white

WM-3835 Usage And Synthesis

Uses

WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1].

Biological Activity

WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound th at acts as a potent, selective, Ac-CoA competitive and reversible inhibitor of HBO1, KAT6A, and TIP60 acetyltransferases (IC50 = 0.030, 0.017 and 0.312 μM, respectively). WM-3835 is non-cytotoxic, dose-dependently, and rapidly decreases H3K14Ac levels (IC50 = 0.341 μM) and inhibits AML cells growth (IC50 = 0.297 μM in Molm13). Induces apoptosis, downregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kg, i.p.).

in vivo

IC 50

HBO1

storage

Store at -20°C

References

[1] Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615. DOI:10.7150/thno.55655

WM-3835(2229025-70-9)Related Product Information

• 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine
• WM-2474
• MOZ-IN-3