CTPB Chemical Properties

Boiling point:

560.7±50.0 °C(Predicted)

Density 

1.104±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble

form 

White to off-white crystalline solid.

pka

12.27±0.70(Predicted)

color 

white to off-white

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

InChIKey

OYBMVMAXKOGYDC-UHFFFAOYSA-N

SMILES

C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1OCC

Safety Information

WGK Germany 

3

CTPB Usage And Synthesis

Description

CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2

Uses

CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.

Definition

ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.

IC 50

CBP/p300

References

[1] KARANAM BALASUBRAMANYAM. Small molecule modulators of histone acetyltransferase p300.[J]. The Journal of Biological Chemistry, 2003, 278 21: 19134-19140. DOI:10.1074/jbc.m301580200
[2] K. MANTELINGU. Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzyme Structure: Probed by Surface-Enhanced Raman Spectroscopy[J]. The Journal of Physical Chemistry B, 2007, 111 17: 4527-4534. DOI:10.1021/jp067655s

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