CTPB

Product Name: CTPB
CAS No.: 586976-24-1
Chemical Name: CTPB
Synonyms: CTPB;CAS:586976-24-1;CTPB, 10 mM in DMSO;HAT Activator, CTPB;CTPB (enzyme inhibitor);CTPB (enzyme activator);CTPB, p300 HAT activator;N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE;Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
CBNumber: CB0840372
Molecular Formula: C31H43ClF3NO2
Formula Weight: 554.13
MOL File: 586976-24-1.mol

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CTPB Property

Boiling point:: 560.7±50.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble
form: White to off-white crystalline solid.
pka: 12.27±0.70(Predicted)
color: white to off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: OYBMVMAXKOGYDC-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1OCC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: EPS001
Product name: HAT Activator, CTPB
Purity: ≥97% (H-NMR)
Packaging: 1mg
Price: $119
Updated: 2023/01/07

Sigma-Aldrich

Product number: EPS001
Product name: HAT Activator, CTPB
Purity: ≥97% (H-NMR)
Packaging: 5mg
Price: $336
Updated: 2023/01/07

Cayman Chemical

Product number: 19570
Product name: CTPB
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 19570
Product name: CTPB
Purity: ≥98%
Packaging: 5mg
Price: $156
Updated: 2024/03/01

Adipogen Life Sciences

Product number: AG-CR1-0141-M001
Product name: CTPB
Purity: ≥98%(HPLC)
Packaging: 1mg
Price: $30
Updated: 2021/12/16

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CTPB Chemical Properties,Usage,Production

Description

CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2

Uses

CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.

Definition

ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.

IC 50

CBP/p300

References

[1] KARANAM BALASUBRAMANYAM. Small molecule modulators of histone acetyltransferase p300.[J]. The Journal of Biological Chemistry, 2003, 278 21: 19134-19140. DOI:10.1074/jbc.m301580200
[2] K. MANTELINGU. Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzyme Structure: Probed by Surface-Enhanced Raman Spectroscopy[J]. The Journal of Physical Chemistry B, 2007, 111 17: 4527-4534. DOI:10.1021/jp067655s

CTPB Preparation Products And Raw materials

Raw materials

Preparation Products

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CTPB Suppliers

China 80 Switzerland 1 United States 8 USA 1 Global 90

Wuhamplov Biotechnology Co., LTD

Tel: 00-18372743325 18372743325
Email: 18372743325@163.cn
Country: China
ProdList: 4930
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 960
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

586976-24-1, CTPBRelated Search:

2-N-HEXYL-4-PENTYNOIC ACID APICIDIN BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Vorinostat salfluverine 3'-TRIFLUOROMETHYL-O-TOLUANILIDE CTPB

N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE

CTPB

Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl

CTPB (enzyme activator)

CTPB (enzyme inhibitor)

HAT Activator, CTPB

CTPB, p300 HAT activator

CTPB, 10 mM in DMSO

CAS:586976-24-1

586976-24-1

C31H43ClF3NO2