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CTPB

Product Name
CTPB
CAS No.
586976-24-1
Chemical Name
CTPB
Synonyms
CTPB;HAT Activator, CTPB;CTPB (enzyme inhibitor);CTPB (enzyme activator);N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE;Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
CBNumber
CB0840372
Molecular Formula
C31H43ClF3NO2
Formula Weight
554.13
MOL File
586976-24-1.mol
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CTPB Property

Boiling point:
560.7±50.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
White to off-white crystalline solid.
pka
12.27±0.70(Predicted)
color 
white to off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
EPS001
Product name
HAT Activator, CTPB
Purity
≥97% (H-NMR)
Packaging
1mg
Price
$119
Updated
2023/01/07
Sigma-Aldrich
Product number
EPS001
Product name
HAT Activator, CTPB
Purity
≥97% (H-NMR)
Packaging
5mg
Price
$336
Updated
2023/01/07
Cayman Chemical
Product number
19570
Product name
CTPB
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
19570
Product name
CTPB
Purity
≥98%
Packaging
5mg
Price
$156
Updated
2024/03/01
Adipogen Life Sciences
Product number
AG-CR1-0141-M001
Product name
CTPB
Purity
≥98%(HPLC)
Packaging
1mg
Price
$30
Updated
2021/12/16
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CTPB Chemical Properties,Usage,Production

Description

CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2

Uses

CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.

Definition

ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.

References

1) Balasubramanyam?et al.?(2003),?Small molecule modulators of histone acetyltransferase p300; J. Biol. Chem.,?278?19134 2) Mantelingu?et al.?(2007),?Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy; J. Phys. Chem. B.,?111?4527

CTPB Preparation Products And Raw materials

Raw materials

Preparation Products

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CTPB Suppliers

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586976-24-1, CTPBRelated Search:

2-N-HEXYL-4-PENTYNOIC ACID APICIDIN BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Vorinostat salfluverine 3'-TRIFLUOROMETHYL-O-TOLUANILIDE CTPB

  • N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE
  • CTPB
  • Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
  • CTPB (enzyme activator)
  • CTPB (enzyme inhibitor)
  • HAT Activator, CTPB
  • 586976-24-1
  • C31H43ClF3NO2