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CTPB

Product Name
CTPB
CAS No.
586976-24-1
Chemical Name
CTPB
Synonyms
CTPB;HAT Activator, CTPB;CTPB (enzyme inhibitor);CTPB (enzyme activator);N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE;Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
CBNumber
CB0840372
Molecular Formula
C31H43ClF3NO2
Formula Weight
554.13
MOL File
586976-24-1.mol
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CTPB Property

Boiling point:
560.7±50.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
White to off-white crystalline solid.
pka
12.27±0.70(Predicted)
color 
white to off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
EPS001
Product name
HAT Activator, CTPB
Purity
≥97% (H-NMR)
Packaging
1mg
Price
$119
Updated
2023/01/07
Sigma-Aldrich
Product number
EPS001
Product name
HAT Activator, CTPB
Purity
≥97% (H-NMR)
Packaging
5mg
Price
$336
Updated
2023/01/07
Cayman Chemical
Product number
19570
Product name
CTPB
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
19570
Product name
CTPB
Purity
≥98%
Packaging
5mg
Price
$156
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
HCH0352650
Product name
CTPB
Purity
95.00%
Packaging
1MG
Price
$165.9
Updated
2021/12/16
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CTPB Chemical Properties,Usage,Production

Description

CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2

Uses

CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.

Definition

ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.

References

1) Balasubramanyam?et al.?(2003),?Small molecule modulators of histone acetyltransferase p300; J. Biol. Chem.,?278?19134 2) Mantelingu?et al.?(2007),?Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy; J. Phys. Chem. B.,?111?4527

CTPB Preparation Products And Raw materials

Raw materials

Preparation Products

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CTPB Suppliers

Wuhamplov Biotechnology Co., LTD
Tel
00-18372743325 18372743325
Email
18372743325@163.cn
Country
China
ProdList
4930
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2988
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq:1580084073
Email
1580084073@qq.com
Country
China
ProdList
650
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4009
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58

586976-24-1, CTPBRelated Search:


  • N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE
  • CTPB
  • Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
  • CTPB (enzyme activator)
  • CTPB (enzyme inhibitor)
  • HAT Activator, CTPB
  • 586976-24-1
  • C31H43ClF3NO2