Basic information Safety Supplier Related

APICIDIN

Basic information Safety Supplier Related

APICIDIN Basic information

Product Name:
APICIDIN
Synonyms:
  • Apicidin (OSI 2040)
  • APICIDIN, FUSARIUM SPECIES
  • Ccris 9163
  • Apicidin Ia
  • Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl)
  • Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
  • OSI 2040
  • Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
CAS:
183506-66-3
MF:
C34H49N5O6
MW:
623.78
Product Categories:
  • antibiotic
Mol File:
183506-66-3.mol
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APICIDIN Chemical Properties

Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: ~1mg/mL
form 
solid
pka
13.09±0.70(Predicted)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
HS Code 
29419090

MSDS

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APICIDIN Usage And Synthesis

Chemical Properties

Solid

Uses

Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.

Uses

Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis.

Enzyme inhibitor

This fungal metabolite and potential oral chemotherapeutic agent (FW = 623.79 g/mol; CAS 183506-66-3), also known as [cyclo(N-O-methyl-L- tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], is an antiprotozoal agent. It is cell permeable and is a strong inhibitor of histone deacetylase (IC50 = 0.7 nM). Apicidin also inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Apicidin’s low bioavailability of apicidin is mainly due to the P-gycoprotein-mediated efflux.

APICIDINSupplier

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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Alabiochem Tech.Co., Ltd.
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0512-58900862;0512-56727736
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sales@alabiochem.com;sales@alabiochem.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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17727448752,0755-83725681-603
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rex.liu@phystandard.com;tom.liu@phystandard.com
Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399-
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isunpharm@qq.com