Basic information Safety Supplier Related

HC TOXIN

Basic information Safety Supplier Related

HC TOXIN Basic information

Product Name:
HC TOXIN
Synonyms:
  • HC TOXIN FROM HELMINTHOSPORIUM CARBONUM
  • Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
  • Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
  • HC toxin I
  • Toxin I
  • Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
  • Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
  • Cyclo(aoe-Pro-Ala-ala)
CAS:
83209-65-8
MF:
C21H32N4O6
MW:
436.51
Product Categories:
  • Cell Signaling and Neuroscience
  • Mold
  • Toxins and Venoms
Mol File:
83209-65-8.mol
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HC TOXIN Chemical Properties

Boiling point:
819.2±65.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 10 mg/ml; Methanol: 10 mg/ml
form 
lyophilized powder
pka
13.33±0.70(Predicted)
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

MSDS

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HC TOXIN Usage And Synthesis

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Uses

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

HC TOXINSupplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD
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Guangzhou Isun Pharmaceutical Co., Ltd
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Sigma-Aldrich
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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