Basic information Safety Supplier Related

OXAMFLATIN

Basic information Safety Supplier Related

OXAMFLATIN Basic information

Product Name:
OXAMFLATIN
Synonyms:
  • CS-2473
  • Metacept 3
  • METACEPT 3;OXAMFLATIN
  • (E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide
  • (2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide
  • Oxamflatin (Metacept-3)
  • 2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
CAS:
151720-43-3
MF:
C17H14N2O4S
MW:
342.37
Product Categories:
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Antitumour
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
Mol File:
151720-43-3.mol
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OXAMFLATIN Chemical Properties

Melting point:
98-100°C
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 13 mg/mL, soluble
form 
solid
pka
7.75±0.10(Predicted)
color 
Light yellow to yellow
Stability:
Light sensitive
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
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OXAMFLATIN Usage And Synthesis

Chemical Properties

Red-Brown Solid

Uses

Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.

Definition

ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.

Enzyme inhibitor

This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).

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