OXAMFLATIN
OXAMFLATIN Basic information
- Product Name:
- OXAMFLATIN
- Synonyms:
-
- CS-2473
- Metacept 3
- METACEPT 3;OXAMFLATIN
- (E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide
- (2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide
- Oxamflatin (Metacept-3)
- 2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
- CAS:
- 151720-43-3
- MF:
- C17H14N2O4S
- MW:
- 342.37
- Product Categories:
-
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Antitumour
- Amines
- Aromatics
- Inhibitors
- Intermediates & Fine Chemicals
- Mol File:
- 151720-43-3.mol
OXAMFLATIN Chemical Properties
- Melting point:
- 98-100°C
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 13 mg/mL, soluble
- form
- solid
- pka
- 7.75±0.10(Predicted)
- color
- Light yellow to yellow
- Stability:
- Light sensitive
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
OXAMFLATIN Usage And Synthesis
Chemical Properties
Red-Brown Solid
Uses
Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.
Definition
ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.
Enzyme inhibitor
This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).
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