ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Epigenetics > HDAC inhibitors > Tubacin
Tubacin
Tubacin Basic information
- Product Name:
- Tubacin
- Synonyms:
-
- Tubacin
- N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide
- N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide Tubacin
- N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide
- Tubacin, >=98%
- BML-GR362
- N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-di
- Tubacin (BML-GR362)
- CAS:
- 537049-40-4
- MF:
- C41H43N3O7S
- MW:
- 721.86
- Product Categories:
-
- Inhibitors
- Mol File:
- 537049-40-4.mol
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Tubacin Chemical Properties
- Melting point:
- 155 - 157°C
- storage temp.
- -20°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to tan
- InChIKey
- BHUZLJOUHMBZQY-UHHSDZQINA-N
- SMILES
- C(NC1=CC=C([C@H]2O[C@@H](CSC3=NC(C4=CC=CC=C4)=C(C4=CC=CC=C4)O3)C[C@@H](C3=CC=C(CO)C=C3)O2)C=C1)(=O)CCCCCCC(NO)=O |&1:6,8,29,r|
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Tubacin Usage And Synthesis
Uses
Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).
Definition
ChEBI: N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide is a member of 1,3-oxazoles.
Biochem/physiol Actions
Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.
target
HDAC6
TubacinSupplier
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