Tubacin Chemical Properties

Melting point:

155 - 157°C

storage temp. 

-20°C

solubility 

DMSO: ≥10mg/mL

form 

powder

color 

white to tan

InChIKey

BHUZLJOUHMBZQY-UHHSDZQINA-N

SMILES

C(NC1=CC=C([C@H]2O[C@@H](CSC3=NC(C4=CC=CC=C4)=C(C4=CC=CC=C4)O3)C[C@@H](C3=CC=C(CO)C=C3)O2)C=C1)(=O)CCCCCCC(NO)=O |&1:6,8,29,r|

Safety Information

WGK Germany 

3

Tubacin Usage And Synthesis

Found

Tubacin was first discovered by Stuart Schreiber's laboratory through a multidimensional chemical genetic screen of 7392 small molecules. Tubacin induces acetylation of α-tubulin (EC50 = 2.9 μM) without causing a marked increase in acetylation of histones (EC50 = 217 μM). Also, tubacin does not induce HSP90 acetylation. Tubacin does not affect global histone deacetylation, gene expression profiling, or cell cycle progression.

Description

Tubacin: an HDAC6 Selective Inhibitor.
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004μM). It dose-dependently boosted the release of influenza A virus (IAV) progeny through the increase of acetylated microtubules to effectively move viral components to the plasma membrane. It could reduce the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Tubacin was demonstrated as a host-targeting agent with preventive and therapeutic activities against the Japanese encephalitis virus. Concentration in cell culture experiments typically ranges from 2-50μM[1].

Uses

Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).

Definition

ChEBI: N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide is a member of 1,3-oxazoles.

Biochem/physiol Actions

Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.

target

HDAC6

References

[1] Chien-Yi Lu. “Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis.” International Journal of Molecular Sciences 18 5 (2017).

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