2S,4R-Sacubitril
2S,4R-Sacubitril Basic information
- Product Name:
- 2S,4R-Sacubitril
- Synonyms:
-
- [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxobutyl)amino]-α-methyl-, 4-ethyl ester, (αR,γS)-rel-
- CAS:
- 2307668-79-5
- MF:
- C25H31NO5
- MW:
- 425.53
- Mol File:
- 2307668-79-5.mol
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2S,4R-Sacubitril Chemical Properties
- Boiling point:
- 658.5±55.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.76±0.10(Predicted)
- form
- Oil
- color
- Colorless to light yellow
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2S,4R-Sacubitril Usage And Synthesis
Description
2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
References
[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.
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2S,4R-Sacubitril(2307668-79-5)Related Product Information
- LCZ696(valsartan + sacubitril) impurity 35
- [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-methyl ester, calcium salt (2:1), (αR,γS)-
- LCZ696(valsartan + sacubitril) impurity 31
- [1,1'-Biphenyl]-4-pentanoic acid, γ-(acetylamino)-α-methyl-, (αR,γS)-
- LCZ696(valsartan + sacubitril) impurity 34
- Sacubatrava valsartan sodium hydrate
- Sacubitril Impurity 43
- Sacubitril Sodium
- Sacubitril Methyl esterQ: What is Sacubitril Methyl ester Q: What is the CAS Number of Sacubitril Methyl ester
- Sacubitrilat-d5