2S,4R-Sacubitril Chemical Properties

Boiling point:

658.5±55.0 °C(Predicted)

Density 

1.136±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

4.76±0.10(Predicted)

form 

Oil

color 

Colorless to light yellow

2S,4R-Sacubitril Usage And Synthesis

Description

2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

Uses

2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

References

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.

2S,4R-Sacubitril(2307668-79-5)Related Product Information

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