N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE Chemical Properties

Boiling point:

617.5±55.0 °C(Predicted)

Density 

1.013±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

0.1 M Na2CO3: 11 mg/ml; DMF: 50 mg/ml; DMSO: 33 mg/ml; Ethanol: 50 mg/ml

form 

ethanol solution

pka

3.31±0.10(Predicted)

Safety Information

Hazard Codes 

F

Risk Statements 

11

Safety Statements 

7-16

RIDADR 

UN 1170 3/PG 2

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE Usage And Synthesis

Description

N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Uses

N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Definition

ChEBI: N-acetyl-s-geranylgeranyl-l-cysteine is a diterpenoid.

References

[1] CRAIG VOLKER. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues[J]. FEBS Letters, 1991, 295 1: Pages 189-194. DOI: 10.1016/0014-5793(91)81415-5
[2] D PéREZ-SALA. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates.[J]. Biochemical Journal, 1992, 284 ( Pt 3): 835-840. DOI: 10.1042/bj2840835

N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE(139332-94-8)Related Product Information

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