AFC Chemical Properties

Boiling point:

566.1±50.0 °C(Predicted)

Density 

1.038±0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)

pka

3.31±0.10(Predicted)

form 

Pale yellow oil.

color 

Yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

LogP

5.860 (est)

Safety Information

HazardClass 

IRRITANT

AFC Usage And Synthesis

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Chemical Properties

Yellow-red oil

Uses

Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.

Definition

ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.

References

1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515 2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495 3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183 4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643 5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700

AFC(135304-07-3)Related Product Information

• AC-CYS(FARNESYL)-OME
• Z-ARG-ARG-AFC
• Z-IETD-AFC,Z-ILE-GLU-THR-ASP-AFC
• AFC
• FA-CYS(FARNESYL)-OH
• N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE
• Z-ASP-GLN-MET-ASP-AFC,Z-DQMD-AFC
• Z-VAL-LYS-LYS-ARG-AFC,Z-VKKR-AFC
• Z-RGFFL-AFC HCL,Z-ARG-GLY-PHE-PHE-LEU-AFC HCL
• Z-ALA-AFC
• Z-MET-AFC
• Z-LYS-AFC
• Z-GGR-AFC,Z-GLY-GLY-ARG-AFC
• Z-ALA-ALA-ASP-AFC
• Z-VAL-GLU-ILE-ASP-AFC,Z-VEID-AFC
• VLR-AFC
• VLK-AFC
• Z-GLY-PRO-ARG-AFC,Z-GRP-AFC