AFC
AFC Basic information
- Product Name:
- AFC
- Synonyms:
-
- AFC
- AC-CYSTEINE(FARNESYL)-OH
- AC-CYS(FARNESYL)-OH
- ACETYL-S-FARNESYL-L-CYSTEINE
- N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE
- N-ACETYL-S-FARNESYL-L-CYSTEINE
- N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
- n-acetyl-s-farnesylcysteine
- CAS:
- 135304-07-3
- MF:
- C20H33NO3S
- MW:
- 367.55
- Mol File:
- 135304-07-3.mol
AFC Chemical Properties
- Boiling point:
- 566.1±50.0 °C(Predicted)
- Density
- 1.038±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
- pka
- 3.31±0.10(Predicted)
- form
- Pale yellow oil.
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- LogP
- 5.860 (est)
AFC Usage And Synthesis
Description
N-
Chemical Properties
Yellow-red oil
Uses
Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.
Definition
ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.
in vivo
Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl[1].
| Animal Model: | TPA-induced ear acute inflammation in mouse[1] |
| Dosage: | 2000?μg/20?μl |
| Administration: | 2000?μg/20?μl; Applied on ear |
| Result: | Inhibited ear edema, as measured by ear weight. |
References
[1] C VOLKER. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction.[J]. The Journal of Biological Chemistry, 1991, 266 32: 21515-21522.
[2] Y XU. Inhibition of capacitative Ca2+ entry into cells by farnesylcysteine analogs.[J]. Molecular Pharmacology, 1996, 50 6: 1495-1501.
[3] J. ROSADO S S. Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton.[J]. The Ukrainian Biochemical Journal, 2000, 13 1: 183-192. DOI:10.1042/bj3470183
[4] JOEL S. GORDON . Topical N-acetyl-S-farnesyl-L-cysteine Inhibits Mouse Skin Inflammation, and Unlike Dexamethasone, its Effects Are Restricted to the Application Site[J]. Journal of Investigative Dermatology, 2008, 128 3: Pages 643-654. DOI:10.1038/sj.jid.5701061
[5] KATAYUN ADHAMI. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells[J]. Experimental Dermatology, 2012, 21 9: 700-705. DOI:10.1111/j.1600-0625.2012.01562.x
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AFC(135304-07-3)Related Product Information
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