4-amino-2,3,5,6-tetradeuterio-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide Chemical Properties

Boiling point:

504.876±52.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.562±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

solubility 

DMSO: slightly soluble; Methanol: slightly soluble

form 

A solid

4-amino-2,3,5,6-tetradeuterio-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide Usage And Synthesis

Description

Sulfamethizole-d₄ is intended for use as an internal standard for the quantification of sulfamethizole by GC- or LC-MS. Sulfamethizole is a broad-spectrum sulfonamide antibiotic (MIC₉₀s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).¹ It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.

Uses

Sulfamethizole-d4-1 is the deuterium labeled Sulfamethizole[1]. Sulfamethizole is a sulfathiazole antibacterial agent[2][3].

References

1. Wambaugh, M.A., Shakya, V.P.S., Lewis, A.J., et al. High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance PLoS Biol. 15(6):e2001644,(2017).

4-amino-2,3,5,6-tetradeuterio-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide(2470130-12-0)Related Product Information

• SULFATHIAZOLE-D4
• Sulfadimethoxine-d6
• Sulfamethazine-D4
• 4-amino-2,3,5,6-tetradeuterio-N-quinoxalin-2-ylbenzenesulfonamide
• SULFAMERAZIN-D4
• 4-amino-2,3,5,6-tetradeuterio-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
• SulphanilaMide-d4
• INDEX NAME NOT YET ASSIGNED