Amlodipine mesylate
Amlodipine mesylate Basic information
- Product Name:
- Amlodipine mesylate
- Synonyms:
-
- 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
- 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di
- 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid
- Amlodipine mesylate USP/EP/BP
- 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1
- CAS:
- 246852-12-0
- MF:
- C20H25ClN2O5.CH4O3S
- MW:
- 0
- Mol File:
- 246852-12-0.mol
Amlodipine mesylate Chemical Properties
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Amlodipine mesylate Usage And Synthesis
Uses
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3].
in vivo
Amlodipine mesylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
| Animal Model: | ATP2B1loxP/loxP mice[4] |
| Dosage: | 5 mg/kg/day |
| Administration: | Subcutaneously implanted osmotic pump for 2 weeks |
| Result: | Significantly decreased the blood pressure. |
IC 50
L-type calcium channel
References
[1] Kishen G. Bulsara, et al. Amlodipine.
[2] Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. DOI:10.2165/00003495-199550030-00009
[3] Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. DOI:10.1016/j.ejphar.2004.04.006
[4] Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. DOI:10.1038/hr.2017.92
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