Antazoline hydrochloride
Antazoline hydrochloride Basic information
- Product Name:
- Antazoline hydrochloride
- Synonyms:
-
- 2-Phenyl-benzyl-amino-methylimidazolin hydrochloride
- Phenazoline hydrochloride
- LABOTEST-BB LT00134672
- BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE HCL
- 2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE HCL
- 2-(N-BENZYLANILINOMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE
- 2-(N-BENZYLANILINOMETHYL) IMIDAZOLINE HYDROCHLORIDE
- ANTAZOLINE HCL
- CAS:
- 2508-72-7
- MF:
- C17H20ClN3
- MW:
- 301.81
- EINECS:
- 219-719-8
- Product Categories:
-
- Histamine receptor
- 2508-72-7
- Mol File:
- 2508-72-7.mol
Antazoline hydrochloride Chemical Properties
- Melting point:
- 238 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- color
- White to Off-White
- Merck
- 14,680
- CAS DataBase Reference
- 2508-72-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- NJ2150000
- HS Code
- 2933.29.4300
MSDS
- Language:English Provider:SigmaAldrich
Antazoline hydrochloride Usage And Synthesis
Chemical Properties
White or almost white crystalline powder
Originator
Antistine HCl,Ciba,US,1948
Uses
Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
Uses
Antihistaminic;H1 antagonist
Uses
Imidazoline binding site ligand and an antihistamine
Manufacturing Process
15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Therapeutic Function
Antihistaminic
Biological Activity
Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.
Antazoline hydrochlorideSupplier
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