ANTAZOLINE PHOSPHATE Chemical Properties

Melting point:

194-198°

storage temp. 

Refrigerator

solubility 

DMSO, Methanol

color 

White

CAS DataBase Reference

154-68-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933290000

MSDS

• Language:English Provider:SigmaAldrich

ANTAZOLINE PHOSPHATE Usage And Synthesis

Uses

Antazoline Phosphate acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.

General Description

Antazoline phosphate, 2-[(Nbenzylanilino)methyl]-2-imidazoline dihydrogen phosphate,is a bitter, white to off-white crystalline powder thatis soluble in water. It has a pKa of 10.0, and a 2% solutionhas a pH of about 4.5. Antazoline, like the ethylenediamines,contains an N-benzylanilino group linked to a basicnitrogen through a two-carbon chain.
Antazoline is less active than most of the other antihistaminicdrugs, but it is characterized by the lack of local irritation.The more soluble phosphate salt is applied topicallyto the eye in a 0.5% solution. The less soluble hydrochlorideis given orally. In addition to its use as an antihistamine, antazolinehas more than twice the local anesthetic potency ofprocaine and also exhibits anticholinergic actions.

ANTAZOLINE PHOSPHATE(154-68-7)Related Product Information

• Antazoline
• Phenamazoline
• 2-METHYL-2-IMIDAZOLINE
• DIETHYLAMINE PHOSPHATE
• Antazoline hydrochloride
• ANTAZOLINE PHOSPHATE