Basic information Safety Supplier Related

Wandonorm

Basic information Safety Supplier Related

Wandonorm Basic information

Product Name:
Wandonorm
Synonyms:
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (+-)-, propanedioate (1:1) (salt)
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), propanedioate (1:1) (salt) (9CI)
  • Bopindolol hydrogen malonate
  • LT 31-200
  • Propanedioic acid, compd. with (+-)-2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)
  • Propanedioic acid, compd. with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)
  • Wandonorm
  • Cyclobenzaprine-d
CAS:
82857-38-3
MF:
C26H32N2O7
MW:
484.54148
Mol File:
82857-38-3.mol
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Wandonorm Chemical Properties

storage temp. 
Store at -20°C
solubility 
Water: 5mM
form 
White solid.
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Wandonorm Usage And Synthesis

Uses

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

Definition

ChEBI: Bopindolol malonate is a benzoate ester.

in vivo

Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1]. Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2].

Animal Model:Male Wistar rats (260-300 g)[2]
Dosage:0.3, 1 and 3 mg/kg
Administration:IP; single dosage
Result:Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg.
Decreased the heart rate in a dose-dependent manner.

References

[1] Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41(1):130-49. DOI:10.2165/00003495-199141010-00010
[2] H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. DOI:10.1016/0306-3623(93)90319-s
[3] Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. DOI:10.1248/bpb.18.1066
[4] Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19(1):9-24. DOI:10.1111/j.1527-3466.2001.tb00180.x

WandonormSupplier

BOC Sciences
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BOC Sciences
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