2-Pyridylethylamine Chemical Properties

Melting point:

198-200 °C(Solv: ethanol (64-17-5))

Boiling point:

92-93 °C12 mm Hg(lit.)

Density 

1.021 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.536(lit.)

Flash point:

213 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

pK1: 4.24(+2);pK2: 9.78(+1) (25°C,μ=0.05)

form 

Liquid

Specific Gravity

1.021

color 

Clear colorless to yellow

Water Solubility 

Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils.

Sensitive 

Air Sensitive

BRN 

111208

CAS DataBase Reference

2706-56-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyridineethanamine(2706-56-1)

EPA Substance Registry System

2-Pyridineethanamine (2706-56-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-34

Safety Statements 

26-36-45-36/37/39

RIDADR 

2735

WGK Germany 

3

F 

10-34

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:2-Aminoethylpyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Pyridylethylamine Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

2-(2-Aminoethyl)pyridine is used as active pharmaceutical ingredients.

Definition

ChEBI: An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2.

Biological Activity

Low doses of histamine or H1R agonist 2-pyridylethylamine (2-PEA) into the knee-joint were found to decrease formalin-induced articular nociception in rats. The pharmacological blockade and neurotoxic ablation of cells expressing neuropeptide Y1 receptor (Y1R) in the spinal cord were able to prevent the antinociceptive effect produced by the intra-articular administration of the histamine H1 receptor (H1R) agonist, 2-pyridylethilamine (2-PEA), in the formalin-induced articular incapacitation in rats[1].

References

[1] Eduardo Souza-Silva. “Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model.” Brain Research 1735 (2020): Article 146757.

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