substance P (3-11) Chemical Properties

Boiling point:

1546.0±65.0 °C(Predicted)

Density 

1.267±0.06 g/cm3(Predicted)

pka

13.26±0.46(Predicted)

substance P (3-11) Usage And Synthesis

Uses

Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5].

in vivo

References

[1] Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10. PMID:838240
[2] Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8. DOI:10.1007/s11095-006-0068-1
[3] Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11. DOI:10.1016/0196-9781(85)90142-1
[4] Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9. DOI:10.1164/ajrccm/138.1.151
[5] Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23(1):157-65. DOI:10.1016/s0196-9781(01)00592-7

substance P (3-11)(51165-11-8)Related Product Information

• SUBSTANCE P
• SUBSTANCE P (2-11)
• SUBSTANCE P (6-11)
• Substance P (1-7)(TFA)
• NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97%
• (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
• Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA
• Galanin (1-16), mouse, porcine, rat TFA
• NEUROPEPTIDE F
• GALANIN, PORCINE
• GLY-LEU-MET-NH2
• H-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2
• H-LEU-PRO-GLY-LEU-PRO-SER-ALA-ALA-SER-SER-GLU-ASP-ALA-GLY-GLN-SER-NH2
• SUBSTANCE P (1-9)
• NEUROPEPTIDE FF
• NEUROPEPTIDE Y (HUMAN, RAT)
• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME
• SUBSTANCE P