4-(Piperazino)indole Chemical Properties

Melting point:

204-206°C

Boiling point:

421.5±25.0 °C(Predicted)

Density 

1.182±0.06 g/cm3(Predicted)

RTECS 

NM1302400

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

soluble in DMSO, Water

pka

18.78±0.30(Predicted)

form 

Solid

CAS DataBase Reference

84807-09-0

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2933998090

4-(Piperazino)indole Usage And Synthesis

Chemical Properties

Brown Solid

Uses

4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.

Synthesis

To the reaction solution, 4-aminoindole (2 g, 15.2 mmol), bis(2-chloroethyl)amine hydrochloride (3.2 g, 18.2 mmol) and potassium carbonate (4.2 g, 30.4 mmol) were added sequentially to isopropanol (30 mL). The reaction mixture was stirred at 90 °C for 48 hours. Upon completion of the reaction, the mixture was diluted by adding dichloromethane (50 mL) and methanol (50 mL) to the mixture. The reaction mixture was filtered to remove insoluble matter and the filtrate was concentrated under reduced pressure and dried by rotary evaporator. Finally, the residue was purified using silica gel column chromatography (eluent ratio of dichloromethane/methanol (v/v) = 10/1) to afford the target product 4-(1-piperazinyl)-1H-indole as a brown solid (2.78 g, 90.8% yield).

References

[1] Patent: CN105367472, 2016, A. Location in patent: Paragraph 0179; 0180; 0181; 0182
[2] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 19-20

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