1-Amino-4-methylpiperazine Chemical Properties

Boiling point:

172-175 °C (lit.)

Density 

0.957 g/mL at 25 °C (lit.)

vapor pressure 

1.29hPa at 25℃

refractive index 

1.4835-1.4855

Flash point:

62 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

water: soluble

form 

Viscous Solution

pka

7?+-.0.42(Predicted)

color 

Clear

Water Solubility 

miscible

Sensitive 

Air & Light Sensitive

BRN 

103334

InChIKey

RJWLLQWLBMJCFD-UHFFFAOYSA-N

LogP

-1.61 at 25℃

CAS DataBase Reference

6928-85-4(CAS DataBase Reference)

NIST Chemistry Reference

1-Amino-4-methylpiperazine(6928-85-4)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

24/25-36-26

RIDADR 

2733

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29335995

MSDS

• Language:English Provider:1-Amino-4-methylpiperazine
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Amino-4-methylpiperazine Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

1-Amino-4-methylpiperazine has been used:
in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-amine
synthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-amine
synthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-amine
synthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-amine
synthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-amine
synthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine

Application

1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease.

Preparation

1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.

Flammability and Explosibility

Not classified

1-Amino-4-methylpiperazine(6928-85-4)Related Product Information

• BUTYLAMINE HYDROCHLORIDE
• 1-AMINOHEPTADECANE
• 1-AMINONONADECANE
• Rifampicin
• 4-[(2-METHOXYETHYL)AMINO]-1-METHYLPIPERAZINE
• 1-AMINO-4-METHYLPIPERAZINE DIHYDROCHLORIDE MONOHYDRATE