2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Chemical Properties

Boiling point:

274℃

Density 

1.344

Flash point:

120℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

Appearance

Light brown to brown Solid

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE Usage And Synthesis

Synthesis

Example 8: Synthesis of N-(3-hydroxyphenethyl)-2,6-dimethylthieno[2,3-d]pyrimidin-4-amine (final compound 22). a) Preparation of 2-amino-5-methylthiophene-3-carboxamide; according to Scheme 5 Step 1: 2-amino-5-methylthiophene-3-carbonitrile (4.00 g, 28.9 mmol) was dissolved in concentrated sulphuric acid (38.8 ml), and the reaction was stirred for 20 hours at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water (250 g) and the pH was adjusted with concentrated sodium hydroxide solution to 7. Subsequently, the mixture was extracted with ethyl acetate, the organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (Flashmart Pack: 85g / 60-40um, eluent: ethyl acetate) to afford 2-amino-5-methyl-3-thiophenecarboxamide (3.10g, 69% yield) as a brown solid.

References

[1] Patent: WO2006/30031, 2006, A1. Location in patent: Page/Page column 57

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