(S)-3-HYDROXYBUTYRIC ACID Chemical Properties

Melting point:

45-48 °C

alpha 

25 º (C=6% IN H2O)

Boiling point:

269.2±0.0 °C(Predicted)

Density 

1.195±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

pka

4.36±0.10(Predicted)

form 

solid

color 

White

optical activity

[α]20/D +25±1°, c = 6% in H2O

Water Solubility 

Water : 50 mg/mL (480.31 mM)

BRN 

1720567

InChI

InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m0/s1

InChIKey

WHBMMWSBFZVSSR-VKHMYHEASA-N

SMILES

C(O)(=O)C[C@@H](O)C

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:SigmaAldrich

(S)-3-HYDROXYBUTYRIC ACID Usage And Synthesis

Uses

(S)-3-Hydroxybutanoic acid is a metabolite and a disease marker of depression. 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.

Definition

ChEBI: The S-enantiomer of 3-hydroxybutyric acid; a normal human metabolite, that has been found elevated in geriatric patients remitting from depression.

IC 50

Human Endogenous Metabolite

storage

Room temperature

References

[1] Khouri H, et al., Acetoacetate and d- and l-β-hydroxybutyrate have distinct effects on basal and insulin-stimulated glucose uptake in L6 skeletal muscle cells. Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720. DOI:10.1152/ajpcell.00718.2023

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