Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Alanine derivatives >  Brivanib alaninate

Brivanib alaninate

Basic information Safety Supplier Related

Brivanib alaninate Basic information

Product Name:
Brivanib alaninate
Synonyms:
  • BMS-582664;BMS 582664;BMS582664
  • CS-362
  • L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
  • (2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aMinopropanoate
  • Brivanib alaninate BMS-540215
  • (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664)
  • Bms 582664
  • Bms582664
CAS:
649735-63-7
MF:
C22H24FN5O4
MW:
441.46
Product Categories:
  • Inhibitors
  • Anti-cancer & immunity
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
649735-63-7.mol
More
Less

Brivanib alaninate Chemical Properties

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH
form 
Yellow powder.
pka
16.08±0.30(Predicted)
color 
White to brown
More
Less

Brivanib alaninate Usage And Synthesis

Uses

BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.

Uses

A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.

Definition

ChEBI: Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib.

target

VEGFR2

Brivanib alaninateSupplier

QINGDAO CARELONGPHARMATECH CO.,LTD Gold
Tel
0532-0532-88191853 13061484198
Email
sales@carelongchem.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Email
sales@jingyan-chemical.com