ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Proteases > Proteasome inhibitors > (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Basic information
- Product Name:
- (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
- Synonyms:
-
- MLN2238
- IxazoMib
- (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
- IXAZOMIB;MLN 2238;MLN-2238
- CS-1976
- 1-(2-(2,5-dichlorobenzamido)acetamido)- 3-methylbutylboronic acid
- B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
- ixazomib(MLN2238)
- CAS:
- 1072833-77-2
- MF:
- C14H19BCl2N2O4
- MW:
- 361.03
- EINECS:
- 810-246-8
- Product Categories:
-
- Inhibitors
- Inhibitor
- apis
- Mol File:
- 1072833-77-2.mol
More
Less
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Chemical Properties
- Melting point:
- >142°C (subl.)
- Density
- 1.306
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- pka
- 9.67±0.43(Predicted)
- form
- Solid
- color
- White to Pale Yellow
More
Less
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Usage And Synthesis
Uses
Ixazomib is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.
Definition
ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixa omib citrate, it is used in combination therapy for treatment of multiple myeloma.
target
chymotrypsin-like proteolytic (β5) site of the 20S proteasome
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acidSupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Adamas Reagent, Ltd.
- Tel
- 400-6009262 16621234537
- chenyj@titansci.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Jinan Trio PharmaTech Co., Ltd.
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
More
Less
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid(1072833-77-2)Related Product Information
- Ixazomib citrate (USAN)
- Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-
- Ixazomib Impurity 1
- CUDC-101
- Brivanib alaninate
- AC480 (BMS-599626)
- 1H-indazole-7-carboxylic acid
- tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate
- Niraparib
- (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate
- Piperidine, 3-(4-bromophenyl)-
- (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate
- 4-piperidin-3-ylaniline
- CHEMBRDG-BB 7959525
- Methyl 3-formyl-2-nitrobenzoate
- Bortezomib
- MLN9708
- MK-2206 2HCl