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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Basic information

Product Name:
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Synonyms:
  • MLN2238
  • IxazoMib
  • (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
  • IXAZOMIB;MLN 2238;MLN-2238
  • CS-1976
  • 1-(2-(2,5-dichlorobenzamido)acetamido)- 3-methylbutylboronic acid
  • B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
  • ixazomib(MLN2238)
CAS:
1072833-77-2
MF:
C14H19BCl2N2O4
MW:
361.03
EINECS:
810-246-8
Product Categories:
  • Inhibitors
  • Inhibitor
  • apis
Mol File:
1072833-77-2.mol
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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Chemical Properties

Melting point:
>142°C (subl.)
Density 
1.306
storage temp. 
-20°C Freezer
solubility 
DMSO (Sparingly), Methanol (Slightly)
pka
9.67±0.43(Predicted)
form 
Solid
color 
White to Pale Yellow
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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Usage And Synthesis

Uses

Ixazomib is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.

Definition

ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixa omib citrate, it is used in combination therapy for treatment of multiple myeloma.

target

chymotrypsin-like proteolytic (β5) site of the 20S proteasome

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acidSupplier

Shanghai Boyle Chemical Co., Ltd.
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BeiJing Hwrk Chemicals Limted
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0757-86329057 18934348241
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Adamas Reagent, Ltd.
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Shanghai Hanhong Scientific Co.,Ltd.
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Jinan Trio PharmaTech Co., Ltd.
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+86 (531) 88811783
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sales@trio-pharmatech.com (International market)
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(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid(1072833-77-2)Related Product Information