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MK-2206 2HCl

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MK-2206 2HCl Basic information

Product Name:
MK-2206 2HCl
Synonyms:
  • MK-2206
  • MK-2206 Dihydrochloride
  • 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
  • MK 2206 2HCL;MK2206 2HCL
  • CS-260
  • MK2206; MK-2206; MK 2206; MK2206 DIHYDROCHLORIDE; MK2206 HCL.
  • 8-[4-(1-AMinocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride
  • 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
CAS:
1032350-13-2
MF:
C25H22ClN5O
MW:
443.94
Product Categories:
  • Inhibitor
  • PI3K/Akt/mTOR
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
1032350-13-2.mol
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MK-2206 2HCl Chemical Properties

Melting point:
>255°C (dec.)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml with warming)
form 
Yellow powder.
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety Information

HS Code 
2933998090
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MK-2206 2HCl Usage And Synthesis

Description

MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

Uses

A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vi vo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents.

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.

References

1) Hirai?et al.?(2010),?MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther.?9?1956 2) Lai?et al.?(2012),?A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J.?447?137 3) Jiao?et al.?(2013),?MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem.?382?217

MK-2206 2HClSupplier

Xianning Shen Lan Biomedical Research and Development Co., Ltd. Gold
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