MK 0557
MK 0557 Basic information
- Product Name:
- MK 0557
- Synonyms:
-
- MK 0557
- trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
- (1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
- CS-2471
- MK0557;MK 0557
- Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-
- N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
- CAS:
- 328232-95-7
- MF:
- C22H19FN4O3
- MW:
- 406.41
- Mol File:
- 328232-95-7.mol
More
Less
MK 0557 Chemical Properties
- Melting point:
- 240.0-240.6 °C
- Boiling point:
- 708.7±60.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
- form
- A crystalline solid
- pka
- 13.40±0.20(Predicted)
- color
- White to off-white
More
Less
MK 0557 Usage And Synthesis
Description
MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.
MK 0557Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
Hangzhou J&H Chemical Co., Ltd.
- Tel
- 0571-+86-571-87396432
- sales@jhechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696,15000506266 15000506266
SPIRO PHARMA
- Tel
- eric_feng1954@126.com
More
Less
MK 0557(328232-95-7)Related Product Information
- MK-2206 2HCl
- MK-5172
- Mk-2461 .
- (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT
- Omarigliptin (MK-3102)
- MK-8998
- MK-4101
- MK8745
- mk-1064
- (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
- MK-0812 (Succinate)
- MKC9989
- MK-1775
- SCH900776
- MK-0752
- MKC3946
- MK-3903