Basic information Safety Supplier Related

MKC3946

Basic information Safety Supplier Related

MKC3946 Basic information

Product Name:
MKC3946
Synonyms:
  • MKC3946;MKC-3946;MKC 3946
  • MKC3946
  • 1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-
  • 2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde
  • Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946
CAS:
1093119-54-0
MF:
C21H20N2O3S
MW:
380.46
Mol File:
1093119-54-0.mol
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MKC3946 Chemical Properties

Boiling point:
591.6±50.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
form 
A crystalline solid
pka
8.18±0.50(Predicted)
color 
White to yellow
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MKC3946 Usage And Synthesis

Biological Activity

MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.

in vivo

In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.

target

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MKC3946Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Email
sales@zehanbiopharma.com
Shanghai Beckham Medical Technology Co., Ltd
Tel
021-13816613772 13816613772
Email
huahero21@sina.com
TargetValue
IRE1α endoribonuclease
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