Ixazomib citrate (USAN) Chemical Properties

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:100.0(Max Conc. mg/mL);193.38(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);193.38(Max Conc. mM)

form 

Solid

pka

3.59±0.10(Predicted)

color 

White to off-white

InChIKey

MBOMYENWWXQSNW-AWEZNQCLSA-N

SMILES

O1C(=O)C(CC(O)=O)(CC(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C

Ixazomib citrate (USAN) Usage And Synthesis

Uses

Ixazomib Citrate is a reversible boronic acid proteasome inhibitor.

Definition

ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diy }diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.

Ixazomib citrate (USAN)(1239908-20-3)Related Product Information

• MLN9708
• Ixazomib Impurity 1
• Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-
• (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
• Repaglinide
• Bendamustine
• Ibrutinib
• Bortezomib
• Carfilzomib