2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Chemical Properties

Melting point:

162℃ (Decomposition)

Boiling point:

296.8±33.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

6.43±0.58(Predicted)

form 

Powder

color 

Light yellow to yellow

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Usage And Synthesis

Uses

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

Biological Activity

Poloxime is a hydrolysis product of poloxin, a non-competitive ATP inhibitor of Plk1, which can properly inhibit the activity of Plk1.

in vitro

target

IC 50

PLK1

References

[1] Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4. DOI:10.1016/j.bmcl.2014.12.060
[2] Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8. DOI:10.1021/cb3004379