9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile Chemical Properties

Melting point:

>300°C

Boiling point:

612.0±55.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.47±0.40(Predicted)

color 

White to Off-White

Stability:

Light Sensitive

9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile Usage And Synthesis

Uses

9-?Ethyl-?8-?iodo-?6,?6-?dimethyl-?11-?oxo-?6,?11-?dihydro-?5H-?benzo[b]?carbazole-?3-?carbonitrile is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Process impurity.