ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > AVL 292 benzenesulfonate
AVL 292 benzenesulfonate
AVL 292 benzenesulfonate Basic information
- Product Name:
- AVL 292 benzenesulfonate
- Synonyms:
-
- AVL 292 benzenesulfonate
- AVL-292 (benzenesulfonate)
- AVL292 benzenesulfonate
- Spebrutinib (AVL-292) benzenesulfonate
- AVL292 BENZENESULFONATE; AVL 292 BENZENESULFONATE; SPEBRUTINIB BESYLATE; CC-292 BESYLATE
- AVL-292 besylate
- CC-292 besylate)
- Spebrutinib besylate (AVL-292 benzenesulfonate
- CAS:
- 1360053-81-1
- MF:
- C28H28FN5O6S
- MW:
- 581.62
- Mol File:
- 1360053-81-1.mol
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AVL 292 benzenesulfonate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
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AVL 292 benzenesulfonate Usage And Synthesis
Uses
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays.
References
[1] Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. DOI:10.1124/jpet.113.203489
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