BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Chemical Properties

Melting point:

208-210 °C (decomp)

Boiling point:

728.2±70.0 °C(Predicted)

Density 

1.349±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: ≥ 54 mg/mL (98.52 mM)

form 

Solid

pka

3.94±0.20(Predicted)

color 

Light yellow to yellow

BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Usage And Synthesis

Uses

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. IC50 value: 63 nM Target: CaMKII

References

[1] Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8. DOI:10.1016/j.bmcl.2010.09.005

BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-(1208123-85-6)Related Product Information

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