TZ-9 Chemical Properties

Boiling point:

675.9±65.0 °C(Predicted)

Density 

1.477±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml

pka

3.69±0.10(Predicted)

form 

Powder

color 

Light yellow to yellow

InChI

1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22)

InChIKey

RRRDZFQRNJTKHL-UHFFFAOYSA-N

SMILES

C1=CC=C(C=C1)NC2=NC(=NC(=N2)N)COC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

Safety Information

WGK Germany 

WGK 2

Storage Class

11 - Combustible Solids

TZ-9 Usage And Synthesis

Uses

TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells[1].

Biological Activity

Cell permeable: yes', 'Primary Target
Rad6B/HHR6B', 'Reversible: yes

References

[1] Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013 Apr;12(4):373-83. DOI:10.1158/1535-7163.MCT-12-0793