1,1,3-Trichloroacetone Chemical Properties

Melting point:

9-11 °C(lit.)

Boiling point:

88-90 °C76 mm Hg(lit.)

Density 

1.512 g/mL at 20 °C(lit.)

vapor pressure 

30-350Pa at 20-50℃

refractive index 

n20/D 1.491

Flash point:

80

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Chloroform, Methanol

form 

Oil

color 

Clear Colourless

BRN 

1746647

InChIKey

ZWILTCXCTVMANU-UHFFFAOYSA-N

LogP

0.45

CAS DataBase Reference

921-03-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanone, 1,1,3-trichloro-(921-03-9)

Safety Information

Hazard Codes 

T+,N

Risk Statements 

25-26-34-50/53-68-21

Safety Statements 

26-36/37/39-45-60-61-28

RIDADR 

UN 3390 6.1/PG 1

WGK Germany 

3

RTECS 

UC3840000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29147000

Toxicity

mmo-sat 50 mL/plate ENMUDM 7,163,85

MSDS

• Language:English Provider:SigmaAldrich

1,1,3-Trichloroacetone Usage And Synthesis

Description

1,1,3-Trichloroacetone is direct-acting mutagens in the Ames/Salmonella assay. It is precursor for the generation of 1,3-dihalo oxyallyl intermediates, which undergo [4 + 3] cycloadditions with a host of 1,3-diene systems.

Chemical Properties

Light yellow transparent liquid

Uses

1,1,3-Trichloroacetone was used in base-induced solvolyses of [3.2.1]Bicyclic α,α′-dichloro ketones.

Uses

1,1,3-Trichloroacetone is a reagent used to synthesize chlorinated 5-hydroxy-4-methyl-2(5H)-furanones and mucochloric acid. In addition, it can also be used to synthesize (+)-Phorbol. Phorbol derivatives are important for biomedical research and capable of stimulating T-cell activation, proliferation and cytokine production.

Safety Profile

Poison by inhalation. Corrosiveand lachrymator. Mutation data reported. Combustibleliquid. When heated to decomposition it emits toxic fumesof Clí.

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