DIPHENYLAMINE HYDROCHLORIDE
DIPHENYLAMINE HYDROCHLORIDE Basic information
- Product Name:
- DIPHENYLAMINE HYDROCHLORIDE
- Synonyms:
-
- N-PHENYLANILINE HYDROCHLORIDE
- Diphenylamine hydrochloride,99%
- DiphenylaMine Hydrochlori...
- DIPHENYLAMINE HYDROCHLORIDE
- n-phenyl-benzenaminhydrochloride
- diphenylammonium chloride
- DiphenylamineHCl
- 2-propenoic acid 1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl ester
- CAS:
- 537-67-7
- MF:
- C12H12ClN
- MW:
- 205.68
- EINECS:
- 208-675-5
- Mol File:
- 537-67-7.mol
DIPHENYLAMINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 180 °C
- storage temp.
- <0°C
- form
- powder to crystal
- color
- White to Almost white
- InChIKey
- JEFJSEIUEJBMSR-UHFFFAOYSA-N
- CAS DataBase Reference
- 537-67-7(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenamine, N-phenyl-, hydrochloride (537-67-7)
MSDS
- Language:English Provider:ACROS
DIPHENYLAMINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties
white crystalline powder
Uses
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent[1][2][3][4].
in vivo
Diphenylamine hydrochloride is excreted in rats through urine and bile[1].
Diphenylamine (10 mg/kg, orally, single dose) hydrochloride lowers blood sugar in hyperglycemic rabbits[2].
| Animal Model: | Hyperglycemic rabbit[2] |
| Dosage: | 10 mg/kg; single dose |
| Administration: | Oral |
| Result: | Reduced blood sugar by 61.4% two hours after administration. |
References
[1] W E Alexander, et al. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet Toxicol. 1965 Oct;3(4):571-9. DOI:10.1016/s0015-6264(65)80203-6
[2] M S Karawya, wt al. Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Prod. 1984 Sep-Oct;47(5):775-80. DOI:10.1021/np50035a003
[3] Safe S, et al. Identification of toxic impurities in commercial diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17(2):204-7. DOI:10.1007/BF01685551
[4] Masubuchi Y, et al. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292(3):982-7. PMID:10688613
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