PYR-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE Chemical Properties

storage temp. 

−20°C

form 

solid

Sequence

{Pyr}-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Safety Information

WGK Germany 

3

PYR-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE Usage And Synthesis

Uses

(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits[1].

References

[1] Takahashi-Ito K, et.al. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochem Biophys Res Commun. 2017 Nov 4;493(1):158-163. DOI:10.1016/j.bbrc.2017.09.058

PYR-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE(183449-57-2)Related Product Information

• PYR-GLY-ARG-PNA
• PYR-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-VAL-LEU-THR-NH2
• FMRF-LIKE PEPTIDE
• MBP 4-14
• PYR-GLN-PHE-PHE-GLY-LEU-MET-NH2
• SEPTIDE
• PYR-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
• PYR-PHE-PHE-GLY-LEU-MET-NH2
• Pyr3] – beta – Amyloid (3 – 40),Human
• (D-Asp1)-Amyloid β-Protein (1-42)
• (Gly22)-Amyloid β-Protein (1-42)
• β-Amyloid (18-28)
• β-Amyloid (13-27)
• β- Amyloid (1-34)
• β- Amyloid (4-10)
• AMYLOID BETA-PROTEIN (1-38)
• (Gln)-Amyloid β-Protein (1-40)
• AMYLOID BETA-PROTEIN (33-42)