LEUKOTRIENE D4
LEUKOTRIENE D4 Basic information
- Product Name:
- LEUKOTRIENE D4
- Synonyms:
-
- LEUKOTRIENE D4
- (r-(r*,s*-(e,e,z,z)))-inyl)
- YEESKJGWJFYOOK-IJHYULJSSA-N
- glycine,n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cyste
- leukotriened
- leukotriened(sub4)
- (5S,6R,7E,9E,11E,14E)-6-[2-amino-2-(carboxymethylcarbamoyl)ethyl]sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid
- LEUKOTRIENE D4 (ETHANOL SOLUTION)
- CAS:
- 73836-78-9
- MF:
- C25H40N2O6S
- MW:
- 496.66
- Product Categories:
-
- Arachidonic Acid Cascade
- Fatty Acids
- Leukotrienes
- LeukotrienesLipids
- Lipids in Cell Signaling
- Mol File:
- 73836-78-9.mol
LEUKOTRIENE D4 Chemical Properties
- Boiling point:
- 785.8±60.0 °C(Predicted)
- Density
- 1.162±0.06 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- -70°C
- solubility
- A solution in ethanol
- form
- Liquid.
- pka
- 3.03±0.10(Predicted)
- color
- Colorless to light yellow
Safety Information
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
LEUKOTRIENE D4 Usage And Synthesis
Description
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
Uses
LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle.
Definition
ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).
Biochem/physiol Actions
Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.
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LEUKOTRIENE D4(73836-78-9)Related Product Information
- ISOPROPYL N-PROPYL SULFIDE
- ALLYL ETHYL SULFIDE
- 2-Pentanethiol
- ALLYL N-PROPYL SULFIDE
- 2-Mercapto-3-butanol
- 1,3,5-UNDECATRIENE
- 2-[(2-AMINOETHYL)THIO]ETHAN-1-OL
- CYS-GLY
- 6-Mercaptohexan-1-ol
- LEUKOTRIENE B4-3-AMINOPROPYLAMIDE
- LEUKOTRIENE C4
- 2-HEPTANETHIOL
- ETHYL SEC-BUTYL SULFIDE
- 7-OCTENOIC ACID
- LEUKOTRIENE D4
- Propanamide, 3-mercapto-N-methyl-
- 2-(butylthio)ethanamine
- LEUKOTRIENE A3 METHYL ESTER