4'-Bromopropiophenone Chemical Properties

Melting point:

45-47 °C(lit.)

Boiling point:

138-140 °C14 mm Hg(lit.)

Density 

1.3841 (rough estimate)

refractive index 

1.5720 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), Methanol

form 

powder to crystal

color 

White to Almost white

BRN 

1210311

InChI

InChI=1S/C9H9BrO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3

InChIKey

UOMOSYFPKGQIKI-UHFFFAOYSA-N

SMILES

C(C1=CC=C(Br)C=C1)(=O)CC

CAS DataBase Reference

10342-83-3(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanone, 1-(4-bromophenyl)-(10342-83-3)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29147000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4'-Bromopropiophenone Usage And Synthesis

Description

4'-Bromopropiophenone is used as a raw material for organic synthesis or as a pharmaceutical intermediate reagent. The 4′-Bromopropiophenone can be employed as a starting material for synthesising novel 5-substituted pyrazole derivatives via Suzuki-type coupling with alkenes. These derivatives function as potent CB1 antagonists exhibiting binding affinities comparable to SR 141716A, presenting potential as therapeutic agents for obesity.

Chemical Properties

white to light yellow crystalline powder

Uses

4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.

4'-Bromopropiophenone(10342-83-3)Related Product Information

• 2-Bromopropiophenone, 90-95%,B-Bromopropiophenone,A-BROMOPROPIOPHENONE 98%,2-BROMOPROPIOPHENONE, TECH., 90%,2-BROMOPROPIOPHENONE,-Bromopropiophenon
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