ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > Fevipiprant
Fevipiprant
Fevipiprant Basic information
- Product Name:
- Fevipiprant
- Synonyms:
-
- QAW039
- Fevipiprant
- Fevipipran
- NVP-QAW039
- Fevipiprant(NVP-QAW039)
- Fevipiprant (QAW039)
- 2-Methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridine-3-acetic acid
- NVP-QAW039; NVP-QAW 039; NVP-QAW-039 QAW-039; QAW039; QAW 039; FEVIPIPRANT
- CAS:
- 872365-14-5
- MF:
- C19H17F3N2O4S
- MW:
- 426.41
- Mol File:
- 872365-14-5.mol
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Fevipiprant Chemical Properties
- Boiling point:
- 637.6±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/mL; DMF:PBS(pH7.2) (1:2): 0.33 mg/mL; DMSO: 10 mg/mL; Ethanol: 1 mg/mL
- form
- A crystalline solid
- pka
- 3.33±0.30(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
- InChIKey
- GFPPXZDRVCSVNR-UHFFFAOYSA-N
- SMILES
- C12N(CC3=CC=C(S(C)(=O)=O)C=C3C(F)(F)F)C(C)=C(CC(O)=O)C1=CC=CN=2
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Fevipiprant Usage And Synthesis
Uses
Fevipiprant is used in the oral treatment of asthma and has been successful in targeting severe eosinophilic asthma.Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; known as CRTh2) antagonist and currently in development for the treatment of severe asthma and atopic dermatitis.
in vivo
Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse[3].
| Animal Model: | C57Bl/6 mice[3] |
| Dosage: | 10 mg/kg |
| Administration: | In the drinking water |
| Result: | Efficiently reduced CaCl2-induced AAA formation with diminished elastin degradation, aortic macrophage infiltration, MPO accumulation and MCP-1 expression. |
IC 50
DP2: 1.14 nM (Kd)
FevipiprantSupplier
Shanghai Zhengyi Pharmaceutical Co., Ltd Gold
- Tel
- 17740884366
- derek1229@163.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
Wuhan Vanzpharm Inc.
- Tel
- 027-84492310 13657243668
- wangting@vanzpharm.com
Shanghai AQBioPharma Co., Ltd.
- Tel
- 13661411401
- yinglv.que@aqbiopharma.com.cn