Ethopabate Chemical Properties

Melting point:

148-151 °C

Boiling point:

426.1±35.0 °C(Predicted)

Density 

1.180±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: 50 mg/mL (210.75 mM)

form 

A solid

pka

14.12±0.70(Predicted)

color 

White to off-white

Merck 

13,3781

InChI

InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)

InChIKey

GOVWOKSKFSBNGD-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC

CAS DataBase Reference

59-06-3(CAS DataBase Reference)

EPA Substance Registry System

Ethopabate (59-06-3)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HS Code 

2924296000

MSDS

• Language:English Provider:Ethopabate
• Language:English Provider:SigmaAldrich

Ethopabate Usage And Synthesis

Description

Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.

Chemical Properties

White to Off-White Solid

Uses

A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.

Uses

antidepressant

Definition

ChEBI: Ethopabate is an amidobenzoic acid.

Clinical Use

Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide.

Molecular Interactions

Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones.

Ethopabate(59-06-3)Related Product Information

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