DCEBIO
DCEBIO Basic information
- Product Name:
- DCEBIO
- Synonyms:
-
- DCEBIO
- 5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
- 5,6-DICHLORO-1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-ONE
- 5,6-DICHLORO-1-ETHYL-1H-BENZO[D]IMIDAZOL-2(3H)-ONE
- 2H-Benzimidazol-2-one, 5,6-dichloro-1-ethyl-1,3-dihydro-
- Potassium Channel,KcsA,DCEBIO,inhibit,Inhibitor
- CAS:
- 60563-36-2
- MF:
- C9H8Cl2N2O
- MW:
- 231.08
- Product Categories:
-
- Potassium channel
- Mol File:
- 60563-36-2.mol
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DCEBIO Chemical Properties
- Melting point:
- 205-207 °C(Solv: ethyl acetate (141-78-6))
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: >10mg/mL
- form
- solid
- pka
- 10.28±0.30(Predicted)
- color
- off-white
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MSDS
- Language:English Provider:SigmaAldrich
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DCEBIO Usage And Synthesis
Description
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance.
Uses
DCEBIO is a small Ca2+sensitive K+ channel (SKCa) agonist. It also stimulate nitric oxide (NO) synthesis and vasodilation in resistance arteries.
Definition
ChEBI: DCEBIO is a dichlorobenzene.
Biological Activity
Stimulates Cl - secretion via activation of hIK1 K + channels and the activation of an apical Cl - conductance. More potent than its analog 1-EBIO (1-Ethyl-2-benzimidazolinone ).
storage
Store at RT
DCEBIOSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai Ennopharm Co., Ltd.
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- +86 (21) 6435-5022
T&W GROUP
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- 021-61551611 13296011611
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Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
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Shanghai T&W Pharmaceutical Co., Ltd.
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- +86 21 61551611