6-KETO PROSTAGLANDIN F1ALPHA-D4 Chemical Properties

solubility 

DMF: >100 mg/ml (from 6-keto PGF1a); DMSO: >50 mg/ml (from 6-keto PGF1a); Ethanol: >16 mg/ml (from 6-keto PGF1a); PBS pH 7.2: >3.3 mg/ml (from 6-keto PGF1a

6-KETO PROSTAGLANDIN F1ALPHA-D4 Usage And Synthesis

Description

6-keto Prostaglandin F_1α-d₄ (6-keto PGF_1α-d₄) contains four deuterium atoms at the 3, 3'', 4, and 4'' positions. It is intended for use as an internal standard for the quantification of 6-keto PGF_1α by GC- or LC-MS. 6-keto PGF_1α is the inactive, non-enzymatic hydrolysis product of PGI₂. 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo. When [³H]-PGI₂ is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [³H]-6-keto PGF_1α.

Uses

6-keto Prostaglandin F1α-d4 is the deuterium labeled 6-keto Prostaglandin F1α[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110

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